Abstract
In this paper we examine “gain of function” (GOF) research in virology, which results in a virus that is substantially more virulent or transmissible than its wild antecedent. We examine the typical animal model, the ferret, arguing that it does not easily satisfy potential desiderata for an animal model. We then discuss how these epistemic limitations bear on practical and policy questions around the risks and benefits of GOF research. We conclude with a reflection on how philosophy of science can contribute to policy discussions around the risks, benefits, and relative priority of particular life sciences research.
